Fair & Pure Agaricus Blazei 1300mg - 120 Capsules Vegan

Background/Objectives: Surgical resection of non-small-cell lung cancer (NSCLC) often results in temporary suppression of natural killer cell activity (NKA), potentially increasing the risk of recurrence. This study aimed to evaluate whether multivitamin and mineral complexes containing Agaricus blazei could support postoperative immune recovery. Methods: In this randomized, double-blind, placebo-controlled multicenter pilot trial, 66 patients with stage I–III NSCLC received either a supplement or a placebo for 28 days post-surgery. NKA was assessed using an interferon-γ release assay preoperatively, on postoperative days (POD) 1–4, and on POD 30. Immune cell subsets, cytokine levels, clinical parameters, and quality of life were evaluated. Results: Both groups showed a postoperative decline in NKA, with recovery observed by POD 30. Although the increase in NKA was not statistically significant, the treatment group showed a greater relative recovery (17.8% vs. 9.9%, p = 0.104). Immune profiling demonstrated significantly better preservation of T cells (p = 0.026) and B cells (p = 0.001) as well as a greater reduction in monocytes (p = 0.031) in the treatment group. No significant differences were observed in cytokine levels, body mass index, Eastern Cooperative Oncology Group Performance Status, or patient-reported outcomes. Conclusions: Supplementation with a multivitamin and mineral complex containing Agaricus blazei may contribute to favorable immune modulation in patients undergoing curative surgery for NSCLC. Larger long-term trials are warranted to confirm these findings and facilitate clinical application.

INTRODUCTION Ferroptosis is a recently identified iron-dependent programmed cell death closely linked to the progression of diffuse large B-cell lymphoma (DLBCL). While studies have shown that FA-2-b-β extracted from Agaricus blazei Murill affects various malignancies, its specific role in modulating ferroptosis in DLBCL and the underlying mechanisms are not yet clear. OBJECTIVES This study aims to elucidate the anticancer properties and mechanisms of FA-2-b-β in inducing ferroptosis in DLBCL cells. METHODS The cell counting kit 8 assay was carried out to evaluate the inhibition of cellular proliferation. Ferroptosis was evaluated using the ferrous colorimetric method, together with kits for measuring malondialdehyde (MDA), reduced glutathione (GSH), reactive oxygen species (ROS), western blotting, JC-1 assays, and transmission electron microscopy. Reverse transcriptionquantitative polymerase chain reaction and western blot were conducted to determine whether FA- 2-b-β affected nuclear factor erythroid 2- related factor 2 (Nrf2) and heme oxygenase 1 (HO-1). RESULTS FA-2-b-β induced ferroptosis in DLBCL cells by elevating the ROS and MDA levels, facilitating the accretion of Fe²⁺, diminishing GSH, upregulating the expression of PTGS2, and downregulating the expression of FTH1, SLC7A11, and GPX4. Furthermore, FA-2-b-β caused structural damage to mitochondria and diminished the mitochondrial membrane potential. The ferroptosis triggered by FA-2-b-β also led to the downregulation of Nrf2 and HO-1, thereby regulating the Nrf2/HO-1 pathway. CONCLUSION FA-2-b-β suppressed DLBCL cell growth by inducing ferroptosis through the Nrf2/HO-1 pathway, making it an attractive potential therapeutic option.

Estudio 2025 que examina la eficacia anticancerígena dependiente de la edad de los polisacáridos del hongo Agaricus blazei en cáncer de colon, mediada principalmente por modulación del sistema inmune.

Selenium nanoparticles (Se NPs) primarily reduce cadmium content in plants. However, the mechanism by which Se NPs affect the Cd content in edible mushrooms is unknown. This study addressed this by exogenously adding Se NPs and Cd(NO3)2 to the cultivated substrates of Agaricus blazei Murill (AbM). The results indicated that Cd was easily enriched in the AbM fruiting body, while adding Se NPs significantly decreased the Cd content of AbM by 48.7–69.4%. The percentages of Cd in cell wall fraction (Fw), soluble fraction (Fs), and organelle fraction (Fo) reached 82.9–95.8%, 3.6–15.7%, and 0.6–3.2%, respectively. Se NPs reduced Cd toxicity to AbM by alleviating oxidative stress. Se existed in the fruiting body as selenocysteine (SeCys) and selenomethionine (SeMet). Se NPs could significantly affect the type and content of metabolites in the AbM fruiting body. In conclusion, applying Se NPs to cultivated substrates may mitigate Cd toxicity by reducing Cd uptake into the fruiting body, altering the subcellular distribution of Cd, alleviating oxidative stress, and altering the type, content, and biometabolic pathways of metabolites.