Niacin (B3)
Vitamin B3 in two forms: niacin (nicotinic acid) and niacinamide. Essential for energy metabolism, DNA repair, and nerve function. At high doses, niacin lowers cholesterol.
💡 Absorption: Niacinamide does not cause flushing but also does not lower cholesterol. Niacin causes flushing that diminishes over time or by taking it with food.
⚠️ Caution: Flushing with niacin is common and harmless. Doses >2g/day may cause hepatotoxicity. UL: 35mg for niacinamide from diet, 2000mg in therapeutic use.
📚 Scientific references (3)▼
Nicotinamide (500mg twice daily) reduces non-melanoma skin cancer rate by 23%.
Extended-release niacin raises HDL but did not add clinical benefit to statin therapy.
Niacin-simvastatin combination significantly reduces cardiovascular events.
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