NMN (Nicotinamide Mononucleotide)
Direct precursor of NAD+, an essential coenzyme that declines with age. NAD+ is needed for DNA repair, energy metabolism, and activation of sirtuins (longevity enzymes). Animal studies show reversal of aging markers.
What is it for?
Raises NAD+ for DNA repair and sirtuin activation. Spectacular animal data, promising human data
NAD+ is a cofactor in cellular energy production
NAD+ is important for neuronal function. Preliminary data
NAD+ protects vascular endothelium in animal models
💡 Absorption: Take on an empty stomach in the morning (aligns with the circadian rhythm of NAD+). Sublingual or liposomal forms have greater bioavailability. Store cold for stability.
⚠️ Caution: EU REGULATORY NOTICE: NMN is not authorized as a Novel Food in the EU. Its sale as a dietary supplement is in a regulatory gray area. It is sold on Amazon.es but without official approval. Generally safe in clinical studies up to 1200mg/day. Long-term data are limited. Theoretically could feed pre-existing cancer cells. Do not use during chemotherapy without consulting an oncologist.
Recommended doses
Range: 250 – 1000 mg
Start with 250mg and increase gradually. On an empty stomach in the morning
Range: 250 – 750 mg
Energy effect may be noticed from the first week
Interactions with other supplements
NMN raises NAD+ and resveratrol activates sirtuins that use NAD+. Synergy popularized by David Sinclair.
📚 Scientific references (3)▼
RCT doble ciego en mayores. 12 semanas de NMN mejoro velocidad de marcha, NAD+ sanguineo y calidad de sueno sin efectos adversos.
RCT multicentrico doble ciego en adultos sanos. NMN fue seguro y bien tolerado. Elevo niveles de NAD+ en sangre.
Evaluacion de seguridad en adultos sanos. NMN oral fue seguro sin efectos adversos significativos en biomarcadores clinicos.
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