Milk Thistle
Liver-protective plant whose active compound is silymarin. Protects liver cells from oxidative damage.
💡 Absorption: Look for extracts standardized to 70-80% silymarin. Phytosomal form has better bioavailability.
⚠️ Caution: Generally safe. May interact with medications metabolized by CYP3A4 and CYP2C9.
Recommended doses
Range: 200 – 600 mg
Silymarin 70-80%. Split into 2-3 doses with food
⚕️ Medication interactions
Silymarin from milk thistle may enhance the hypoglycemic effect of metformin.
→ Monitorizar glucemia con mayor frecuencia al iniciar cardo mariano. Ajustar dosis de metformina si necesario.
📚 Scientific references (3)▼
Ensayo cruzado doble ciego en 16 participantes comparando formulación micelar vs. estándar de silimarina. La formulación micelar mostró 18,9x mayor Cmax y 11,4x mayor AUC en 24h.
Revisión sistemática y metaanálisis de ECAs sobre silimarina en hígado graso no alcohólico (NAFLD/NASH). El 65,5% de estudios reportaron reducción de enzimas hepáticas.
Revision sistematica. Silimarina (cardo mariano) mostro hepatoproteccion significativa. Usado clinicamente en intoxicacion por Amanita.
Want to know if Milk Thistle is right for you?
Take our personalized test and discover the ideal supplement combination.
Take the testProduct comparator (4)
Sorted by cost per dose, from cheapest to most expensive
Zenement 
Aldous Bio
HIVITAL
Solgar
💊 Combined products with Milk Thistle
Products that combine Milk Thistle with other supplements
Suplr may receive a commission for purchases made through the links on this page. This does not affect the price you pay or our recommendations, which are based exclusively on scientific evidence.