Vitamin B6
Pyridoxine/P5P, essential for amino acid metabolism, neurotransmitters (serotonin, dopamine, GABA), and immune function.
What is it for?
💡 Absorption: The P5P form (pyridoxal-5-phosphate) is the active form and does not require hepatic conversion. Better option for people with liver issues.
⚠️ Caution: CAUTION: doses >100mg/day long-term cause peripheral neuropathy. UL: 100mg. Symptoms are reversible upon reducing the dose.
Recommended doses
Range: 1.3 – 10 mg
RDA: 1.3-1.7mg. P5P is the active form
Range: 10 – 50 mg
Clinical dose for morning sickness
⚕️ Medication interactions
Vitamin B6 accelerates the peripheral conversion of levodopa to dopamine, reducing the amount that reaches the brain.
→ Evitar suplementos de B6 >10mg/día con levodopa sola. Con carbidopa-levodopa el riesgo es menor pero consultar neurólogo.
📚 Scientific references (3)▼
Higher dietary B6 intake is associated with lower depressive symptoms in elderly.
B6 is essential cofactor in homocysteine-to-cysteine conversion pathway.
Vitamin B6 supplementation reduces premenstrual syndrome symptoms.
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